CHRD

Across TCGA cell cohorts, CHRD mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHRD-associated genes across cancer lineages are FBXW7, SCYGR10, and KRTAP10-8. Each is linked with CHRD in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRD-to-partner and partner-to-CHRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW7 grouped by CHRD-low versus CHRD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRD→partner) and Y-score (partner→CHRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXW7 →	+0.708	+3.120	.006	.009	3	2
SKIN	SCYGR10 →	+0.191	+3.684	<.001	.006	3	2
LUNG_SCLC	KRTAP10-8 →	+0.091	+4.269	<.001	.005	3	1
LUNG_NSCLC_LUSC	ADIG →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR14A2 →	+0.036	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

FBXW7 by CHRD expression — BLOOD_Leukemia

Explore this box plot interactively →