CHRD

Across TCGA cell cohorts, CHRD mutation is significantly associated with the mutation status of many other genes, with 3,686 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRD-associated genes across cancer lineages are HERC1, WDFY3, and MYH6. Each is linked with CHRD in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRD-to-partner and partner-to-CHRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HERC1 grouped by CHRD-low versus CHRD-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRD→partner) and Y-score (partner→CHRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HERC1 →	+3.217	+3.684	.006	.006	1	5
SOFT_TISSUE	WDFY3 →	+3.307	+3.777	.005	.005	1	4
SOFT_TISSUE	MYH6 →	+5.307	+4.651	<.001	<.001	1	4
BLOOD_Leukemia	SHANK1 →	+2.949	+2.275	.001	.001	1	4
UPPER_AERODIGESTIVE_TRACT	CACNA1I →	+5.392	+5.392	.004	.004	1	4
BLOOD_Lymphoma	SEC23A →	+6.014	+6.014	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

HERC1 by CHRD expression — OVARY

Explore this box plot interactively →