CHRAC1

Across TCGA cell cohorts, CHRAC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,830 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHRAC1-associated GO terms across cancer lineages are miRNA-mediated gene silencing by mRNA destabilization, Protein localization to chromatin, and Chromosome condensation. Each is linked with CHRAC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CHRAC1-to-partner and partner-to-CHRAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, miRNA-mediated gene silencing by mRNA destabilization grouped by CHRAC1-low versus CHRAC1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRAC1→partner) and Y-score (partner→CHRAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	miRNA-mediated gene silencing by mRNA destabilization →	+0.182	+0.660	<.001	<.001	3	13
BONE	Protein localization to chromatin →	+0.134	+0.729	.004	.004	3	13
BREAST	Chromosome condensation →	+0.154	+1.030	<.001	.001	3	13
BONE	Nucleosome disassembly →	+0.164	+0.580	.002	.001	3	12
LUNG_SCLC	Protein localization to chromosome →	+0.075	+0.474	.003	.008	3	12
BLOOD_Lymphoma	Positive regulation of DNA metabolic process →	+0.066	+1.133	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,830 associations by consensus.

miRNA-mediated gene silencing by mRNA destabilization by CHRAC1 expression — LUNG_SCLC

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