CHRAC1

Across TCGA pan-cancer cohorts, CHRAC1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CHRAC1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CHRAC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHRAC1 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

UVM, KIRP, and KICH are the cancer types where CHRAC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.366	0.777	<.001	139	view →
KIRP	DFS	Median	All	0.511	0.679	<.001	106	view →
KICH	DFS	Median	All	0.774	1.000	.001	65	view →
LIHC	OS	Tertile	All	0.602	0.787	<.001	63	view →
LGG	OS	Median	All	0.342	0.550	<.001	54	view →
LUAD	OS	Tertile	All	0.242	0.499	<.001	52	view →
PAAD	OS	Quartile	All	0.271	0.547	<.001	47	view →
OV	OS	Median	All	0.742	0.635	.001	34	view →
UCEC	DFS	Tertile	All	0.558	0.797	.001	34	view →
ACC	DFS	Quartile	II,III,IV	0.279	0.780	.005	29	view →
KIRC	DFS	Quartile	All	0.890	0.677	.004	26	view →
SARC	DFS	Median	All	0.373	0.594	.003	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CHRAC1–UVM (OS)

Open the UVM breakdown →