CHPT1

Across TCGA cell cohorts, CHPT1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHPT1-associated genes across cancer lineages are CT47A6, ADAMTS5, and PRAMEF9. Each is linked with CHPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHPT1-to-partner and partner-to-CHPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT47A6 grouped by CHPT1-low versus CHPT1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHPT1→partner) and Y-score (partner→CHPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CT47A6 →	+0.035	+4.285	<.001	.007	3	1
LARGE_INTESTINE	ADAMTS5 →	+0.047	+4.332	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1
LARGE_INTESTINE	NAP1L3 →	+0.344	+3.793	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CT47A6 by CHPT1 expression — STOMACH

Explore this box plot interactively →