CHPT1

Across TCGA pan-cancer cohorts, CHPT1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CHPT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHPT1 RNA is repressed in tumor relative to normal tissue. In most cancer types CHPT1 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and THCA are the cancer types where CHPT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHPT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.677	<.001	11	view →
HNSC	Male	All	−1.171	<.001	9	view →
THCA	Male	All	+0.942	<.001	8	view →
LUSC	Male	All	−0.874	<.001	8	view →
BRCA	All	III,IV	−0.819	<.001	8	view →
UCEC	All	All	−1.776	<.001	6	view →
COAD	All	IV	−0.904	.004	6	view →
LIHC	Male	All	+0.545	<.001	4	view →
KIRC	All	All	−0.306	<.001	4	view →
BLCA	Male	All	−1.008	.006	3	view →
KIRP	All	All	−0.455	.010	2	view →
PRAD	All	All	−0.425	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CHPT1–LUAD

Open the LUAD breakdown →