CHODL

Across TCGA pan-cancer cohorts, CHODL Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHODL data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHODL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHODL expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUAD, ESCA, and UCEC are the cancer types where CHODL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.068	0.677	<.001	12	view →
ESCA	OS	Median	III,IV	0.108	0.563	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	OS	Median	All	0.257	0.688	.049	3	view →
SKCM	DFS	Median	All	0.762	0.612	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHODL–LUAD (OS)

Open the LUAD breakdown →