CHODL

Across TCGA pan-cancer cohorts, CHODL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CHODL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CHODL RNA is repressed in tumor relative to normal tissue. In most cancer types CHODL is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, COAD, and HNSC are the cancer types where CHODL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHODL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−2.176	<.001	11	view →
COAD	Female	III,IV	−1.324	<.001	11	view →
HNSC	All	III,IV	+1.189	<.001	11	view →
KICH	Female	All	−2.657	<.001	9	view →
KIRC	Male	II,III,IV	−1.341	<.001	9	view →
THCA	Female	III,IV	−0.964	<.001	8	view →
LUAD	All	All	+0.747	<.001	8	view →
READ	All	All	−2.122	<.001	7	view →
LUSC	Female	All	+2.155	<.001	6	view →
STAD	All	All	−1.216	<.001	6	view →
BRCA	All	III,IV	−1.033	<.001	6	view →
LIHC	Female	All	+0.148	.041	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CHODL–KIRP

Open the KIRP breakdown →