CHODL

Across TCGA patient cohorts, CHODL protein abundance is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHODL-associated genes across cancer lineages are PRPF6, PHF7, and PLA2G4C. Each is linked with CHODL in more than 1 cancer types. Because this analysis shows association rather than direction, both CHODL-to-partner and partner-to-CHODL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHODL versus PRPF6 in GBM, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHODL→partner) and Y-score (partner→CHODL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF6 →	-0.322	-0.731	.001	.002	3	1
GBM	PHF7 →	-0.364	-0.911	.001	.001	3	1
GBM	PLA2G4C →	+0.754	+0.960	.002	<.001	3	1
GBM	SLC5A5 →	-0.134	-0.814	.003	.002	3	1
GBM	HOXA2 →	-1.398	-0.659	<.001	.007	3	1
GBM	CASP2 →	-0.551	-0.654	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

CHODL vs PRPF6 — GBM

Explore this scatter interactively →