CHODL

Across TCGA patient cohorts, CHODL mutation is significantly associated with the RNA expression of many other genes, with 1,930 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHODL-associated genes across cancer lineages are CENPO, EME1, and CCNB2. Each is linked with CHODL in more than 3 cancer types. Because this analysis shows association rather than direction, both CHODL-to-partner and partner-to-CHODL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPO grouped by CHODL-low versus CHODL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHODL→partner) and Y-score (partner→CHODL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPO →	+0.725	+3.595	<.001	.001	3	4
UCEC	EME1 →	+0.674	+2.425	<.001	.002	3	3
UCEC	CCNB2 →	+0.885	+4.169	<.001	<.001	3	3
UCEC	BOLA3 →	+0.382	+3.584	.008	.002	3	3
UCEC	LSM3 →	+0.580	+2.627	.001	.005	3	3
SKCM	UFD1 →	+0.472	+3.738	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,930 associations by consensus.

CENPO by CHODL expression — UCEC

Explore this box plot interactively →