CHODL

Across TCGA cell cohorts, CHODL mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CHODL-associated genes across cancer lineages are TSPAN16, ADAM30, and OR10C1. Each is linked with CHODL in more than 1 cancer types. Because this analysis shows association rather than direction, both CHODL-to-partner and partner-to-CHODL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by CHODL-low versus CHODL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHODL→partner) and Y-score (partner→CHODL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TSPAN16 →	+0.061	+4.479	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.005	+3.628	.005	.002	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.033	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.022	+3.887	<.001	.002	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.011	+4.266	<.001	.004	3	1
LARGE_INTESTINE	CCL18 →	+0.129	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TSPAN16 by CHODL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →