CHODL-AS1

Across TCGA pan-cancer cohorts, CHODL-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CHODL-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CHODL-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHODL-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

LUSC, KIRP, and HNSC are the cancer types where CHODL-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHODL-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.122	<.001	5	view →
KIRP	All	All	−0.016	.001	5	view →
HNSC	Male	IV	+0.113	.024	3	view →
KIRC	Male	III,IV	−0.012	.025	3	view →
BRCA	All	III,IV	−0.057	.028	2	view →
THCA	Female	All	−0.026	.023	2	view →
LUAD	All	All	+0.117	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CHODL-AS1–LUSC

Open the LUSC breakdown →