CHMP7

Across TCGA cell cohorts, CHMP7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,416 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CHMP7-associated GO terms across cancer lineages are Negative regulation of sister chromatid cohesion, Positive regulation of telomere capping, and Regulation of regulatory ncRNA-mediated heterochromatin formation. Each is linked with CHMP7 in more than 14 cancer types. Because this analysis shows association rather than direction, both CHMP7-to-partner and partner-to-CHMP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sister chromatid cohesion grouped by CHMP7-low versus CHMP7-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP7→partner) and Y-score (partner→CHMP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of sister chromatid cohesion →	+0.149	+0.852	.003	.002	3	15
KIDNEY	Positive regulation of telomere capping →	+0.106	+0.828	<.001	<.001	3	14
STOMACH	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.117	+0.786	.003	<.001	3	13
STOMACH	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.117	+0.786	.003	<.001	3	13
BONE	DNA-templated transcription initiation →	+0.087	+1.131	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.079	+0.835	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,416 associations by consensus.

Negative regulation of sister chromatid cohesion by CHMP7 expression — STOMACH

Explore this box plot interactively →