CHMP7

Across TCGA pan-cancer cohorts, CHMP7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CHMP7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHMP7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where CHMP7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.390	<.001	10	view →
THCA	Male	III,IV	−0.471	<.001	8	view →
KICH	All	All	−0.630	<.001	5	view →
LIHC	Female	All	+0.489	<.001	5	view →
STAD	All	II,III,IV	+0.675	<.001	4	view →
COAD	All	All	−0.254	.008	4	view →
CHOL	Female	All	+2.023	<.001	3	view →
READ	Female	All	−0.761	<.001	2	view →
ESCA	Female	All	+0.589	.018	2	view →
LUAD	Male	II,III,IV	+0.394	.006	2	view →
PRAD	All	All	−0.229	.023	2	view →
BLCA	All	IV	−0.599	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CHMP7–HNSC

Open the HNSC breakdown →