CHMP7

Across TCGA cell cohorts, CHMP7 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHMP7-associated genes across cancer lineages are RASGEF1C, ITGAD, and ACER1. Each is linked with CHMP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP7-to-partner and partner-to-CHMP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by CHMP7-low versus CHMP7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP7→partner) and Y-score (partner→CHMP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.315	+3.404	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.071	+3.145	.008	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	MAGEB1 →	+0.204	+2.878	<.001	.009	3	1
LARGE_INTESTINE	IQCF6 →	+0.194	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

RASGEF1C by CHMP7 expression — LARGE_INTESTINE

Explore this box plot interactively →