CHMP4C

Across TCGA pan-cancer cohorts, CHMP4C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHMP4C data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CHMP4C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHMP4C expression acts as an unfavorable survival marker.

COAD, SKCM, and LGG are the cancer types where CHMP4C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.084	0.874	<.001	48	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	20	view →
LGG	OS	Median	All	0.182	0.909	<.001	12	view →
SCLC	DFS	Median	All	0.192	0.793	.017	6	view →
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHMP4C–COAD (OS)

Open the COAD breakdown →