CHMP4C

Across TCGA pan-cancer cohorts, CHMP4C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHMP4C data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CHMP4C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CHMP4C expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where CHMP4C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.983	0.851	.011	18	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
CCRCC	OS	Quartile	II,III,IV	0.779	1.000	.012	8	view →
LSCC	OS	Tertile	II,III,IV	0.769	0.916	.036	2	view →
HNSC	OS	Tertile	All	1.000	0.948	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHMP4C–UCEC (OS)

Open the UCEC breakdown →