CHMP4C

Across TCGA pan-cancer cohorts, CHMP4C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CHMP4C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHMP4C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP4C is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

LUAD, PDAC, and HNSC are the cancer types where CHMP4C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP4C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.341	<.001	8	view →
PDAC	All	IV	+0.673	<.001	7	view →
HNSC	Male	II,III,IV	−0.272	.004	6	view →
LSCC	All	All	+0.216	<.001	6	view →
COAD	All	II,III,IV	−0.196	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CHMP4C–LUAD

Open the LUAD breakdown →