CHMP4A

Across TCGA patient cohorts, CHMP4A mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP4A-associated genes across cancer lineages are SNORA35, SPANXN4, and MIR519A1. Each is linked with CHMP4A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP4A-to-partner and partner-to-CHMP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA35 grouped by CHMP4A-low versus CHMP4A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4A→partner) and Y-score (partner→CHMP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORA35 →	+0.404	+7.816	<.001	.008	3	2
UCEC	SPANXN4 →	+0.176	+5.358	.005	.006	3	2
UCEC	MIR519A1 →	+0.853	+5.186	<.001	.007	3	2
UCEC	RNU7-180P →	+1.028	+5.242	<.001	.007	3	2
UCEC	KRTAP13-6P →	+0.295	+6.335	<.001	.001	3	2
SKCM	RNU6-839P →	+0.458	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

SNORA35 by CHMP4A expression — SKCM

Explore this box plot interactively →