CHMP2A

Across TCGA patient cohorts, CHMP2A mutation is significantly associated with the RNA expression of many other genes, with 674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP2A-associated genes across cancer lineages are ZNHIT3, TAF9, and TUBGCP5. Each is linked with CHMP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP2A-to-partner and partner-to-CHMP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by CHMP2A-low versus CHMP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP2A→partner) and Y-score (partner→CHMP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.444	+3.724	.004	<.001	3	1
UCEC	TAF9 →	+0.723	+2.721	<.001	.003	3	1
UCEC	TUBGCP5 →	+0.413	+2.354	.006	.003	3	1
UCEC	HNRNPCL3 →	+0.040	+2.193	<.001	.005	3	1
UCEC	IGHV1OR21-1 →	+0.638	+2.765	.001	<.001	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 674 associations by consensus.

ZNHIT3 by CHMP2A expression — UCEC

Explore this box plot interactively →