CHMP2A

Across TCGA pan-cancer cohorts, CHMP2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CHMP2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHMP2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP2A is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where CHMP2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.744	<.001	12	view →
LIHC	Male	II,III,IV	+1.110	<.001	9	view →
BRCA	All	All	+0.322	<.001	6	view →
CHOL	Male	All	+1.259	<.001	5	view →
KICH	All	All	−0.516	<.001	5	view →
PAAD	Male	All	+0.425	.034	4	view →
THCA	All	All	+0.231	.002	4	view →
READ	All	All	−0.402	.023	2	view →
BLCA	All	All	+0.282	.041	2	view →
KIRP	All	II,III,IV	+0.275	.024	2	view →
LUAD	All	IV	−0.254	.032	2	view →
COAD	All	All	−0.218	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CHMP2A–KIRC

Open the KIRC breakdown →