CHMP2A

Across TCGA cell cohorts, CHMP2A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHMP2A-associated genes across cancer lineages are MAGEB4, STRA8, and OR10W1. Each is linked with CHMP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP2A-to-partner and partner-to-CHMP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CHMP2A-low versus CHMP2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP2A→partner) and Y-score (partner→CHMP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRY →	+0.012	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB4 by CHMP2A expression — LARGE_INTESTINE

Explore this box plot interactively →