Across TCGA cell cohorts, CHM mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHM-associated genes across cancer lineages are TMEM202, VN1R4, and PRAMEF9. Each is linked with CHM in more than 1 cancer types. Because this analysis shows association rather than direction, both CHM-to-partner and partner-to-CHM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHM→partner) and Y-score (partner→CHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TMEM202 →	+0.178	+5.754	<.001	.002	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1
LARGE_INTESTINE	FMO1 →	+0.115	+3.658	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

CHM survival (RNA) · tumor vs normal (RNA) · all CHM data types