CHKB

Across TCGA patient cohorts, CHKB mutation is significantly associated with the RNA expression of many other genes, with 511 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHKB-associated genes across cancer lineages are OR5M13P, OR6C74, and RNU6-1222P. Each is linked with CHKB in more than 1 cancer types. Because this analysis shows association rather than direction, both CHKB-to-partner and partner-to-CHKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M13P grouped by CHKB-low versus CHKB-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKB→partner) and Y-score (partner→CHKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5M13P →	+0.038	+5.814	<.001	.001	3	2
BLCA	OR6C74 →	+0.037	+4.899	<.001	.005	3	2
BLCA	RNU6-1222P →	+0.663	+4.497	<.001	.009	3	2
BRCA	TTTY9B →	+0.036	+7.459	<.001	<.001	3	2
BRCA	RPS24P1 →	+0.161	+6.215	<.001	.001	3	2
SKCM	RNU7-137P →	+0.174	+3.990	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 511 associations by consensus.

OR5M13P by CHKB expression — BLCA

Explore this box plot interactively →