Across TCGA pan-cancer cohorts, CHKB-DT RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CHKB-DT’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CHKB-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHKB-DT is over-expressed in tumor.
BLCA, HNSC, and LUAD are the cancer types where CHKB-DT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHKB-DT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.