CHKA

Across TCGA patient cohorts, CHKA mutation is significantly associated with the RNA expression of many other genes, with 1,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHKA-associated genes across cancer lineages are RPSAP38, SLC20A1P3, and HSPE1P20. Each is linked with CHKA in more than 1 cancer types. Because this analysis shows association rather than direction, both CHKA-to-partner and partner-to-CHKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP38 grouped by CHKA-low versus CHKA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKA→partner) and Y-score (partner→CHKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPSAP38 →	+0.241	+4.769	<.001	.001	3	2
COAD	SLC20A1P3 →	+0.073	+5.332	.001	.002	3	2
LUAD	HSPE1P20 →	+0.238	+6.315	<.001	.001	3	2
UCEC	RN7SL248P →	+0.046	+2.783	<.001	.009	3	2
BLCA	RPL23P4 →	+0.119	+3.680	<.001	.009	3	2
SKCM	RPL12P50 →	+0.300	+3.801	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,728 associations by consensus.

RPSAP38 by CHKA expression — COAD

Explore this box plot interactively →