CHIA

Across TCGA pan-cancer cohorts, CHIA Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CHIA data layer compared with 16 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHIA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHIA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUSC, and BLCA are the cancer types where CHIA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
LUSC	OS	Median	III,IV	0.127	0.673	<.001	18	view →
BLCA	DFS	Median	III,IV	0.183	0.576	.002	12	view →
CHOL	OS	Median	All	0.154	0.793	.004	9	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
BRCA	OS	Median	All	0.201	0.580	.024	4	view →
UCEC	DFS	Median	All	0.810	0.631	.031	4	view →
LIHC	DFS	Median	All	0.146	0.555	.037	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CHIA–HNSC (OS)

Open the HNSC breakdown →