CHI3L2

Across TCGA pan-cancer cohorts, CHI3L2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CHI3L2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher CHI3L2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHI3L2 expression acts as an unfavorable survival marker.

GBM and LSCC are the cancer types where CHI3L2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.261	0.518	.003	16	view →
LSCC	DFS	Median	All	0.604	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CHI3L2–GBM (DFS)

Open the GBM breakdown →