CHI3L2

Across TCGA pan-cancer cohorts, CHI3L2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CHI3L2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHI3L2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHI3L2 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where CHI3L2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHI3L2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.581	.001	4	view →
HNSC	Male	All	−0.563	.040	4	view →
LSCC	Male	All	−0.645	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CHI3L2–LUAD

Open the LUAD breakdown →