CHGB

Across TCGA pan-cancer cohorts, CHGB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHGB data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHGB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CHGB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where CHGB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.502	0.898	<.001	63	view →
PDAC	OS	Median	III,IV	0.942	0.587	.001	49	view →
HNSC	DFS	Median	III,IV	0.463	0.788	.006	8	view →
LSCC	DFS	Quartile	All	1.000	0.714	.045	4	view →
GBM	DFS	Quartile	All	0.299	0.553	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHGB–LUAD (OS)

Open the LUAD breakdown →