CHGB

Across TCGA patient cohorts, CHGB mutation is significantly associated with the RNA expression of many other genes, with 1,954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHGB-associated genes across cancer lineages are APOOP2, SNX3P1X, and MTCO3P45. Each is linked with CHGB in more than 2 cancer types. Because this analysis shows association rather than direction, both CHGB-to-partner and partner-to-CHGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOOP2 grouped by CHGB-low versus CHGB-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGB→partner) and Y-score (partner→CHGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	APOOP2 →	+0.655	+5.039	<.001	.008	3	3
LUSC	SNX3P1X →	+0.079	+4.321	<.001	.006	3	3
LGG	MTCO3P45 →	+0.067	+5.363	<.001	.003	3	3
LGG	RN7SL415P →	+0.373	+4.773	<.001	.003	3	3
LGG	TRBVB →	+0.562	+4.760	<.001	.006	3	3
SKCM	MIR4797 →	+0.137	+1.350	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,954 associations by consensus.

APOOP2 by CHGB expression — READ

Explore this box plot interactively →