CHGB

Across TCGA patient cohorts, CHGB mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHGB-associated genes across cancer lineages are Notch1, p27_pT198, and p62 Lck ligand. Each is linked with CHGB in more than 2 cancer types. Because this analysis shows association rather than direction, both CHGB-to-partner and partner-to-CHGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CHGB-low versus CHGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGB→partner) and Y-score (partner→CHGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.207	+3.594	<.001	.001	3	3
UCEC	p27_pT198 →	+0.132	+3.321	.003	.010	3	2
UCEC	p62 Lck ligand →	+0.559	+3.459	<.001	.005	3	2
UCEC	XBP1 →	-0.165	-2.308	.006	.033	3	2
UCEC	ATM →	-0.576	-1.700	.002	.044	3	2
UCEC	Caspase-7-cleavedD198 →	+0.547	+1.894	.029	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by CHGB expression — UCEC

Explore this box plot interactively →