CHFR

Across TCGA patient cohorts, CHFR mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHFR-associated genes across cancer lineages are GAPDH, Mre11, and MSH2. Each is linked with CHFR in more than 1 cancer types. Because this analysis shows association rather than direction, both CHFR-to-partner and partner-to-CHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CHFR-low versus CHFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHFR→partner) and Y-score (partner→CHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.381	+1.807	.044	.025	3	2
UCEC	Mre11 →	-0.074	-1.662	.014	.011	3	2
UCEC	MSH2 →	-0.333	-3.973	<.001	<.001	3	2
UCEC	p53 →	-0.301	-1.700	.027	.042	3	2
UCEC	Annexin-1 →	+0.608	+2.827	.001	.001	3	2
UCEC	ATM →	-0.508	-2.687	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GAPDH by CHFR expression — UCEC

Explore this box plot interactively →