CHFR

Across TCGA pan-cancer cohorts, CHFR RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CHFR data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CHFR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CHFR expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

KIRC, MESO, and ACC are the cancer types where CHFR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.544	0.698	<.001	125	view →
MESO	OS	Median	All	0.275	0.500	<.001	106	view →
ACC	DFS	Median	All	0.246	0.644	<.001	106	view →
LIHC	DFS	Median	All	0.456	0.624	<.001	73	view →
HNSC	DFS	Tertile	IV	0.735	0.539	.001	72	view →
LGG	DFS	Median	All	0.658	0.811	<.001	48	view →
READ	OS	Median	III,IV	0.301	0.931	.007	34	view →
THCA	OS	Median	II,III,IV	0.899	0.987	.001	24	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	24	view →
GBM	DFS	Median	All	0.407	0.174	<.001	21	view →
PRAD	DFS	Median	All	0.906	0.959	.010	18	view →
THYM	OS	Median	All	1.000	0.727	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CHFR–KIRC (OS)

Open the KIRC breakdown →