CHFR

Across TCGA cell cohorts, CHFR mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHFR-associated genes across cancer lineages are ASB17, IQCF5, and ZNF330. Each is linked with CHFR in more than 1 cancer types. Because this analysis shows association rather than direction, both CHFR-to-partner and partner-to-CHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by CHFR-low versus CHFR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHFR→partner) and Y-score (partner→CHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
BLOOD_Leukemia	IQCF5 →	+0.093	+4.786	<.001	<.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.512	+3.067	.007	.009	3	1
LARGE_INTESTINE	GALR3 →	+0.132	+3.865	<.001	.001	3	1
LARGE_INTESTINE	CPO →	+0.129	+3.777	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

ASB17 by CHFR expression — OVARY

Explore this box plot interactively →