CHERP

Across TCGA patient cohorts, CHERP protein abundance is significantly associated with the RNA expression of many other genes, with 20,675 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHERP-associated genes across cancer lineages are NCAPD2, DDX39A, and CSE1L. Each is linked with CHERP in more than 7 cancer types. Because this analysis shows association rather than direction, both CHERP-to-partner and partner-to-CHERP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHERP versus NCAPD2 in HNSC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHERP→partner) and Y-score (partner→CHERP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCAPD2 →	+1.037	+0.220	<.001	<.001	3	8
HNSC	DDX39A →	+0.903	+0.193	<.001	<.001	3	8
HNSC	CSE1L →	+0.744	+0.185	.001	<.001	3	8
LSCC	GTPBP3 →	+0.775	+0.277	<.001	<.001	3	8
OV	CENPH →	+1.001	+0.261	<.001	<.001	3	8
LUAD	SASS6 →	+0.829	+0.159	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,675 associations by consensus.

CHERP vs NCAPD2 — HNSC

Explore this scatter interactively →