CHERP

Across TCGA pan-cancer cohorts, CHERP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CHERP data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher CHERP RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHERP expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

SCLC, KICH, and KIRP are the cancer types where CHERP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Quartile	III,IV	0.873	0.342	<.001	71	view →
KICH	DFS	Tertile	III,IV	0.226	1.000	.005	70	view →
KIRP	DFS	Median	All	0.794	0.912	.003	47	view →
ACC	DFS	Tertile	All	0.345	0.840	<.001	33	view →
SKCM	OS	Median	All	0.284	0.413	.002	27	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
HNSC	DFS	Median	IV	0.410	0.214	.001	21	view →
UCEC	DFS	Median	All	0.805	0.866	.018	16	view →
GBM	DFS	Median	All	0.399	0.184	<.001	15	view →
KIRC	DFS	Median	All	0.712	0.541	.013	14	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	14	view →
BRCA	OS	Quartile	III,IV	0.943	0.833	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CHERP–SCLC (OS)

Open the SCLC breakdown →