CHERP

Across TCGA cell cohorts, CHERP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,091 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHERP-associated GO terms across cancer lineages are DNA-templated transcription initiation, Regulation of protein localization to chromatin, and Positive regulation of T-helper 17 cell lineage commitment. Each is linked with CHERP in more than 18 cancer types. Because this analysis shows association rather than direction, both CHERP-to-partner and partner-to-CHERP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by CHERP-low versus CHERP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHERP→partner) and Y-score (partner→CHERP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated transcription initiation →	+0.093	+1.009	<.001	.002	3	19
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.125	+0.656	<.001	<.001	3	18
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.238	+0.820	<.001	<.001	3	18
BONE	Regulation of DNA repair →	+0.099	+1.110	<.001	<.001	3	18
BONE	Regulation of double-strand break repair →	+0.095	+0.971	<.001	.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.084	+1.256	.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,091 associations by consensus.

DNA-templated transcription initiation by CHERP expression — BONE

Explore this box plot interactively →