CHERP

Across TCGA cell cohorts, CHERP mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHERP-associated genes across cancer lineages are CUEDC2, CD81, and STK11. Each is linked with CHERP in more than 1 cancer types. Because this analysis shows association rather than direction, both CHERP-to-partner and partner-to-CHERP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by CHERP-low versus CHERP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHERP→partner) and Y-score (partner→CHERP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.715	+3.064	<.001	.009	3	1
LARGE_INTESTINE	CD81 →	+0.869	+3.131	<.001	.008	3	1
LARGE_INTESTINE	STK11 →	+0.602	+3.215	.006	.009	3	1
LARGE_INTESTINE	KCNK17 →	+0.065	+3.169	<.001	.001	3	1
LARGE_INTESTINE	UBE2G1 →	+0.632	+3.215	.004	.009	3	1
LARGE_INTESTINE	ELAC1 →	+0.805	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

CUEDC2 by CHERP expression — LARGE_INTESTINE

Explore this box plot interactively →