CHEK1

Across TCGA patient cohorts, CHEK1 mutation is significantly associated with the RNA expression of many other genes, with 970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHEK1-associated genes across cancer lineages are MIR5189, ATF4P1, and MIR4253. Each is linked with CHEK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHEK1-to-partner and partner-to-CHEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5189 grouped by CHEK1-low versus CHEK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK1→partner) and Y-score (partner→CHEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR5189 →	+0.242	+4.588	<.001	.008	3	2
UCEC	ATF4P1 →	+0.044	+2.232	<.001	.007	3	2
LIHC	MIR4253 →	+0.622	+6.676	<.001	<.001	3	2
LUSC	RNU6-1252P →	+0.176	+5.005	<.001	.002	3	2
LIHC	OR9I3P →	+0.054	+5.878	<.001	.002	3	1
LIHC	MIR6070 →	+0.400	+5.878	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 970 associations by consensus.

MIR5189 by CHEK1 expression — BLCA

Explore this box plot interactively →