CHDH

Across TCGA pan-cancer cohorts, CHDH mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CHDH data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CHDH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CHDH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where CHDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.990	0.791	<.001	78	view →
PDAC	OS	Quartile	III,IV	0.612	0.208	.004	37	view →
COAD	DFS	Median	II,III,IV	1.000	0.913	.015	36	view →
LUAD	DFS	Tertile	III,IV	0.379	0.894	.012	15	view →
UCEC	DFS	Quartile	All	1.000	0.800	.009	6	view →
LSCC	DFS	Tertile	II,III,IV	0.480	0.851	.006	6	view →
GBM	OS	Median	All	0.866	0.768	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CHDH–CCRCC (OS)

Open the CCRCC breakdown →