CHD8

Across TCGA patient cohorts, CHD8 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,883 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHD8-associated proteins across cancer lineages are SUPT16H, ACIN1, and SSRP1. Each is linked with CHD8 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHD8-to-partner and partner-to-CHD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHD8 versus SUPT16H in LSCC, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD8→partner) and Y-score (partner→CHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.485	+0.433	<.001	<.001	3	8
GBM	ACIN1 →	+0.228	+0.332	<.001	<.001	3	8
LSCC	SSRP1 →	+0.502	+0.456	<.001	<.001	3	7
GBM	APEX1 →	+0.433	+0.355	<.001	<.001	3	7
LSCC	RBM39 →	+0.264	+0.457	<.001	<.001	3	6
GBM	MTA1 →	+0.500	+0.406	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,883 associations by consensus.

CHD8 vs SUPT16H — LSCC

Explore this scatter interactively →