CHD7

Across TCGA cell cohorts, CHD7 mutation is significantly associated with the RNA expression of many other genes, with 2,588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD7-associated genes across cancer lineages are UBXN8, FRG1, and UGDH. Each is linked with CHD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHD7-to-partner and partner-to-CHD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBXN8 grouped by CHD7-low versus CHD7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD7→partner) and Y-score (partner→CHD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBXN8 →	+0.837	+2.043	<.001	.001	3	3
LARGE_INTESTINE	FRG1 →	+0.341	+2.043	.005	.001	3	3
LARGE_INTESTINE	UGDH →	+0.925	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	HSPA9 →	+0.625	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	IRAK1BP1 →	+0.721	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	AMN1 →	+0.619	+2.459	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,588 associations by consensus.

UBXN8 by CHD7 expression — LARGE_INTESTINE

Explore this box plot interactively →