CHD6

Across TCGA patient cohorts, CHD6 mutation is significantly associated with the RNA expression of many other genes, with 6,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD6-associated genes across cancer lineages are NDUFA6, FANCG, and PIMREG. Each is linked with CHD6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHD6-to-partner and partner-to-CHD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by CHD6-low versus CHD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD6→partner) and Y-score (partner→CHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.470	+1.683	<.001	<.001	3	5
UCEC	FANCG →	+0.329	+1.370	<.001	<.001	3	5
COAD	PIMREG →	+0.683	+4.321	<.001	<.001	3	5
STAD	OIP5 →	+0.611	+2.907	<.001	<.001	3	5
SKCM	NCAPH2 →	+0.512	+1.779	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.432	+1.032	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,613 associations by consensus.

NDUFA6 by CHD6 expression — UCEC

Explore this box plot interactively →