CHD6

Across TCGA pan-cancer cohorts, CHD6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHD6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CHD6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHD6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where CHD6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHD6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.650	<.001	9	view →
THCA	All	II,III,IV	−0.694	<.001	8	view →
COAD	All	All	+0.626	<.001	6	view →
CHOL	Male	All	+1.790	<.001	5	view →
LIHC	All	All	+0.428	<.001	5	view →
STAD	Male	II,III,IV	+0.837	.010	3	view →
BLCA	Female	III,IV	+0.687	.022	3	view →
KICH	All	All	−0.670	.001	3	view →
READ	All	III,IV	+0.754	.043	2	view →
PRAD	All	All	+0.570	<.001	2	view →
UCEC	All	All	−0.414	.006	2	view →
LUSC	All	All	+0.398	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHD6–HNSC

Open the HNSC breakdown →