CHD6

Across TCGA patient cohorts, CHD6 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD6-associated genes across cancer lineages are TFRC, MYH11, and 4E-BP1. Each is linked with CHD6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHD6-to-partner and partner-to-CHD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CHD6-low versus CHD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD6→partner) and Y-score (partner→CHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.340	+1.652	.008	.004	3	5
STAD	MYH11 →	-1.222	-3.169	.013	.017	3	4
COAD	4E-BP1 →	+0.293	+3.169	<.001	.017	3	4
UCEC	Cyclin-B1 →	+0.385	+1.777	.004	.001	3	4
BLCA	eIF4E →	+0.156	+2.186	.005	.032	3	4
COAD	ASNS →	+0.621	+3.700	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

TFRC by CHD6 expression — UCEC

Explore this box plot interactively →