CHD6

Across TCGA cell cohorts, CHD6 mutation is significantly associated with the RNA expression of many other genes, with 668 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD6-associated genes across cancer lineages are OR13D1, MARCOL, and CFAP97D2. Each is linked with CHD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHD6-to-partner and partner-to-CHD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by CHD6-low versus CHD6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD6→partner) and Y-score (partner→CHD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR13D1 →	+0.025	+4.977	<.001	.002	3	3
OESOPHAGUS	MARCOL →	+0.418	+3.906	.003	.001	3	2
BREAST	CFAP97D2 →	+0.026	+3.378	<.001	.006	3	2
BLOOD_Leukemia	SDE2 →	+0.716	+2.489	.001	.007	3	2
SKIN	HAS2 →	-1.109	-3.169	.004	.006	3	2
SKIN	SCYGR10 →	+0.090	+1.962	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 668 associations by consensus.

OR13D1 by CHD6 expression — SOFT_TISSUE

Explore this box plot interactively →