CHD3

Across TCGA patient cohorts, CHD3 mutation is significantly associated with the RNA expression of many other genes, with 5,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD3-associated genes across cancer lineages are UHRF1, ABHD10, and GTSE1. Each is linked with CHD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD3-to-partner and partner-to-CHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by CHD3-low versus CHD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD3→partner) and Y-score (partner→CHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.761	+1.567	<.001	<.001	3	4
SKCM	ABHD10 →	+0.429	+2.254	.008	.001	3	4
SKCM	GTSE1 →	+0.598	+2.254	.004	.001	3	4
COAD	BTBD6 →	+0.388	+3.519	.003	.002	3	4
COAD	TEDC1 →	+0.594	+3.361	<.001	.004	3	4
BLCA	LSM7 →	+0.452	+2.595	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,732 associations by consensus.

UHRF1 by CHD3 expression — UCEC

Explore this box plot interactively →