CHD3

Across TCGA pan-cancer cohorts, CHD3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CHD3 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CHD3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CHD3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and ACC are the cancer types where CHD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.930	0.864	<.001	78	view →
HNSC	DFS	Median	All	0.426	0.258	.001	75	view →
ACC	DFS	Median	All	0.181	0.613	<.001	74	view →
LUAD	DFS	Tertile	II,III,IV	0.588	0.787	.001	48	view →
UVM	DFS	Tertile	II,III,IV	0.403	0.724	.001	41	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LGG	DFS	Median	All	0.880	0.782	<.001	36	view →
BRCA	OS	Tertile	III,IV	0.964	0.838	<.001	35	view →
KIRP	OS	Tertile	II,III,IV	0.221	0.837	.004	30	view →
COAD	OS	Quartile	All	0.493	0.707	.003	28	view →
LUSC	DFS	Median	III,IV	0.509	0.916	.006	24	view →
MESO	DFS	Quartile	IV	0.079	0.608	.009	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CHD3–UCEC (DFS)

Open the UCEC breakdown →