CHD3

Across TCGA cell cohorts, CHD3 mutation is significantly associated with the RNA expression of many other genes, with 1,971 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD3-associated genes across cancer lineages are BRDT, KSR2, and VWC2L. Each is linked with CHD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHD3-to-partner and partner-to-CHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by CHD3-low versus CHD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD3→partner) and Y-score (partner→CHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRDT →	+0.154	+3.342	<.001	.006	3	2
BLOOD_Leukemia	KSR2 →	+0.482	+3.798	<.001	.004	3	2
BLOOD_Leukemia	VWC2L →	+0.013	+3.339	<.001	.006	3	2
LARGE_INTESTINE	EIF3L →	+0.564	+2.546	<.001	.001	3	2
LARGE_INTESTINE	SSR1 →	+0.752	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	IER3IP1 →	+0.604	+2.364	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,971 associations by consensus.

BRDT by CHD3 expression — BLOOD_Leukemia

Explore this box plot interactively →